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Aricept (Donepezil)
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Aricept

Generic Aricept is an effective medication which helps to fight with moderate or mild dementia as a result of Alzheimer's disease. It also improves the ability of patients with Alzheimer's disease to think, to reason, to perceive, to judge, to remember, to recognize. Generic Aricept acts by making the nerve cells in the brain work harder and by detaining the neurotransmitter acetycholine breakdown.

Other names for this medication:
Aldomer, Alzaimax, Alzim, Alzit, Ameloss, Aripez, Asenta, Calofra, Carencil, Cebrocal, Cogiton, Crialix, Cristaclar, Dazolin, Doenza, Domepezil, Donaz, Donecept, Donecil, Donectil, Donepex, Donepezilo, Donepezilum, Donesyn, Donethon, Donopez, Dopezil, Dozept, Dozilax, Dozyl, Elzer, Endoclar, Eranz, Evimal, Fordesia, Kibilis, Lirpan, Memac, Memorin, Memorit, Nepezil, Oldinot, Onefin, Redumas, Symepezil, Synpezil, Valpex, Yasnal

Similar Products:
Galantamine, Rivastigmine

 

Also known as:  Donepezil.

Description

Generic Aricept is a perfect remedy, which helps to fight with moderate or mild dementia as a result of Alzheimer's disease. It also improves the ability of patients with Alzheimer's disease to think, to reason, to perceive, to judge, to remember, to recognize.

Generic Aricept acts by making the nerve cells in the brain work harder and by detaining the neurotransmitter acetycholine breakdown. It is cholinesterase inhibitor.

Aricept is also known as Donepezil.

Generic name of Generic Aricept is Donepezil.

Brand names of Generic Aricept are Aricept, Aricept ODT.

Dosage

The tablet should be dissolved on your tongue and then you should drink water.

Do not crush or chew it.

The usual dose is 5 mg-10 mg a day.

Take Generic Aricept tablets orally with or without food, at the same time every day at bedtime.

Take Generic Aricept once a day.

If you want to achieve most effective results do not stop taking Generic Aricept suddenly.

Overdose

If you overdose Generic Aricept and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Aricept: slow heartbeat, seizure, vomiting, shallow breathing, weak muscle, drooling, severe nausea, blurred vision, dizziness, sweating.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Aricept are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Generic Aricept if you are allergic to Generic Aricept components.

Do not take Generic Aricept if you are pregnant, planning to become pregnant. Do not breast-feed while taking Generic Aricept.

Be careful with Generic Aricept if you take hyoscyamine (such as Levsin, Anaspaz, Cystospaz); glycopyrrolate (such as Robinul); rifampin (such as Rifater, Rifadin, Rifamate); a fungal antibiotic (itraconazole (such as Sporanox), ketoconazole (such as Nizoral), fluconazole (such as Diflucan)); atropine (such as Donnatal); propantheline (such as Pro-Banthine); aspirin or other NSAIDs (mefenamic acid (such as Ponstel), piroxicam (such as Feldene), indomethacin (such as Indocin), ibuprofen (such as Advil, Motrin), naproxen (such as Naprosyn, Aleve), diclofenac (such as Voltaren), etodolac (such as Lodine), flurbiprofen (such as Ansaid), ketoprofen (such as Orudis), ketorolac (such as Toradol), meloxicam (such as Mobic)); mepenzolate (such as Cantil); belladonna; scopolamine (such as Transderm-Scop), methscopolamine (such as Pamine); quinidine (such as Quinaglute, Cardioquin, Quinidex); carbamazepine (such as Tegretol); phenobarbital (such as Solfoton, Luminal); clidinium (such as Quarzan); dicyclomine (such as Bentyl); phenytoin (such as Dilantin); dexamethasone (such as Decadron), methantheline (such as Provocholine); nabumetone (such as Relafen), diflunisal (such as Dolobid).

Be very careful with Generic Aricept if you suffer from or have a history of enlarged prostate, heart rhythm or seizure disorder, epilepsy, problems with urination, asthma, obstructive pulmonary disease.

Be careful with this drug if you are going to have a surgery.

Avoid driving machinery.

It can be dangerous to stop Generic Aricept taking suddenly.

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Data of NPI revealed a significant decrease of BPSD severity and distress of the caregiver in patients of group A compared with group B. Mood disorders (depression, anxiety and apathy) were significantly decreased in subjects treated with donepezil and choline alphoscerate, while their severity and frequency was increased in the other group.

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The results of 13 randomized, double blind, placebo controlled trials demonstrate that treatment for periods of 6 months and one year, with donepezil, galantamine or rivastigmine at the recommended dose for people with mild, moderate or severe dementia due to Alzheimer's disease produced improvements in cognitive function, on average -2.7 points (95%CI -3.0 to -2.3), in the midrange of the 70 point ADAS-Cog Scale. Study clinicians blind to other measures rated global clinical state more positively in treated patients. Benefits of treatment were also seen on measures of activities of daily living and behaviour. None of these treatment effects are large. There is nothing to suggest the effects are less for patients with severe dementia or mild dementia, although there is very little evidence for other than mild to moderate dementia.More patients leave ChEI treatment groups, approximately 29 %, on account of adverse events than leave the placebo groups (18%). There is evidence of more adverse events in total in the patients treated with a ChEI than with placebo. Although many types of adverse event were reported, nausea, vomiting, diarrhoea, were significantly more frequent in the ChEI groups than in placebo. There are four studies, all supported by one of the pharmaceutical companies, in which two ChEIs were compared, two studies of donepezil compared with galantamine, and two of donepezil compared with rivastigmine. In three studies the patients were not blinded to treatment, only the fourth, DON vs RIV/Bullock is double blind. Two of the studies provide little evidence, they are of 12 weeks duration, which is barely long enough to complete the drug titration. There is no evidence from DON vs GAL/Wilcock of a treatment difference between donepezil and galantamine at 52 weeks for cognition, activities of daily living, the numbers who leave the trial before the end of treatment, the number who suffer any adverse event, or any specific adverse event. There is no evidence from DON vs RIV/Bullock of a difference between donepezil and rivastigmine for cognitive function, activities of daily living and behavioural disturbance at two years. Fewer patients suffer adverse events on donepezil than rivastigmine.

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We review four randomised, controlled trials investigating the efficacy of Ginkgo biloba extract EGb 761(®) in elderly patients with Alzheimer or vascular dementia with neuropsychiatric features.

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Delirium is very common in the elderly. It complicates both psychiatric and somatic disorders and is associated with reduced survival, poor functional results, increased duration of hospital stay, and institutionalization. Diagnosis remains difficult in spite of the improvement of the diagnostic criteria, due to the polymorphism of the clinical signs and fluctuation of vigilance and cognition. Age over 70 and previous cognitive impairment are the main risk factors. Precipitating factors are medical and surgical pathologies, intoxications, especially by therapeutic drugs. Delirium can reveal or complicate a previous dementia. Prevention of delirium and care of the delirious patient require the participation of both the medical and nursing staff.

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A series of novel donepezil derivatives was designed, synthesized and evaluated as multifunctional acetylcholinesterase (AChE) inhibitors for the treatment of Alzheimer's disease (AD). The screening results indicated that most of the compounds exhibited potent inhibition of AChE with IC50 values in the nanomolar range. Moreover, these derivatives displayed good antioxidant, Aβ interaction, blood-brain barrier penetration (PAMPA-BBB+) and ADMET properties (in silico). Among them, 5c demonstrated excellent AChE inhibition (IC50: 85 nM for eeAChE, 73 nM for hAChE), metal chelation, and inhibitory effects on self-induced, hAChE-induced and Cu(2+)-induced Aβ1-42 aggregation (18.5%, 72.4% and 46.3%, at 20 μM). Kinetic analysis and molecular modeling studies suggested that 5c could bind simultaneously to the catalytic active site (CAS) and peripheral anionic site (PAS) of AChE. More importantly, 5c exhibited significant neuroprotective potency against Aβ1-42-induced PC12 cell injury. Furthermore, the step-through passive avoidance test showed 5c significantly reversed scopolamine-induced memory deficit and no hepatotoxicity in mice. These results indicated that 5c might be a promising drug candidate for AD therapy.

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International, multicentre, open-label, 30-week extension study of two 24-week, randomised, double-blind, placebo-controlled studies. Participants were ambulatory adults (59% female; mean age, 74.7 +/- 0.3) with a diagnosis of possible or probable VaD and without a diagnosis of Alzheimer's disease, who were medically stable and had completed one of two double-blind studies. All patients received donepezil 5 mg/day for the first 6 weeks, then 10 mg/day (clinician approval required). Assessments were performed at week 6 and every 12 weeks thereafter. The main outcome measure was the Alzheimer's disease Assessment Scale-cognitive subscale (ADAS-cog). Safety/tolerability measures included adverse events (AEs) and physical and laboratory evaluations.

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A total of 28 women aged 46 to 60 years were enrolled. Fourteen women were randomized to receive active drug, 14 to placebo. Two women dropped out of the placebo group. There were no statistically significant differences between treatment groups in post-/pre-dose mean score ratios. No interactions were statistically significant. The P values for tests of equal variances did not reveal a difference in the means. Subjective measures did show some trends toward improvement in memory and cognition.

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Currently, cholinergic therapies for Alzheimer's disease (AD) have been developed and widely accepted based upon an observation that presynaptic cholinergic neurons in the basal nucleus of Meynert that widely project to the cerebral cortices are consistently damaged in AD brains. Since it is likely that the loss of central cholinergic activity may be associated with cognitive worsening in patients with AD, it is hypothesized that cholinergic augmentation could improve the cognitive ability of patients with AD. Cholinesterase inhibitors represent one way of implementing this strategy by inhibiting the breakdown of acetylcholine and increasing its availability in synapses. Indeed, several recent clinical trials of donepezil, galanthamine and rivastigmine have come to the conclusion that these cholinesterase inhibitors have overall beneficial effects in cognitive as well as global functions. American Academy of Neurology recommended a use of cholinesterase inhibitors as a first choice medicine in the treatment of AD. All 3 major studies of Donepezil from USA, Europe and Japan have reached the same conclusion favoring Donepezil in the treatment of mild to moderate AD. Donepezil can also be used as a safe and efficacious drug in the elderly aged 85 or older. Clinical trial of galantamine is in progress in Japan. Moreover, herbal medicines named kami-untan-to and hachimi-jiou-gan have been shown to be beneficial in some priority studies with a small sample size. It is critically needed to widen therapeutic windows in the treatment of AD.

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Epidemiological and animal studies have suggested that dietary fish or fish oil rich in omega-3 fatty acids (omega3), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), may have effects in psychiatric and behavioral symptoms in Alzheimer's disease (AD). An association with APOEomega4 carriers and neuropsychiatric symptoms in AD has also been suggested.

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The majority of patients with Alzheimer's disease will experience behavioral disturbances during the course of their disease. Atypical antipsychotics are used routinely in these situations to treat the psychotic features and agitation. However, atypicals now carry a "black box" warning issued by the Food and Drug Administration on the basis of evidence that their use in geriatric patients with dementia-related psychosis may put patients at increased risk of mortality as a result of cardiovascular or infectious events. An alternative to the atypicals may be the acetylcholinesterase inhibitors and memantine, which have been shown to stabilize cognitive as well as behavioral issues in patients, utilizing the "gold standard" for behavior, the Neuropsychiatric Inventory. Efficacy varies among agents, with the greatest positive effects seen with donepezil, which also has the greatest number of studies. Drug benefits were harder to demonstrate for mild-to-moderate BPSD compared with moderate-to-severe symptoms.

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buy aricept 5mg 2017-07-07

Thirty subjects were administered a daily dose of either 5mg donepezil or placebo for 15days in a double-blind, randomized, cross-over trial. The electroencephalogram during an auditory oddball paradigm was recorded from 58 scalp electrodes. Current source density (CSD Buy Antabuse In Australia ) transformations were applied to EEG epochs. The event-related potential (ERP), inter-trial coherence (ITC: the phase consistency of the EEG spectrum) and event-related spectral perturbation (ERSP: the EEG power spectrum relative to the baseline) were calculated for the target (oddball) stimuli.

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The purpose of this systematic review was to review the current place in therapy of the 4 medications, donepezil, rivastigmine, galantamine, and memantine, approved for the treatment Buy Dapoxetine Singapore of Alzheimer disease (AD) since the publication of Phase III trials.

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All studies evaluating any aspect of TD rivastigmine, including Buy Xenical Online Boots in vivo animal experimentation.

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Behavioural disturbances are common in the course of dementia in Alzheimer's disease (AD) and their treatment is usually difficult. Different pharmacological and non-pharmacological options are employed basing mainly on clinical experience, still the number of well-designed, controlled studies in the field is very small. Novel, atypical neuroleptics, including risperidone might potentially be one of these options, taking into account their good safety profile and clinical efficacy in closely related syndromes. We present the results of a retrospective analysis of 57 outpatients with behavioural symptoms complicating AD treated with risperidone, either alone or in combination with one of the acetylcholinesterase inhibitor (AchEI; donepezil or rivastigmine). Seventy five percent of patients treated responded to risperidone Buy Cialis Mexico with the usual effective dose of 0.5-1 mg/day. The influence of risperidone treatment on behavioural symptomatology was irrespective to the use of AchEI and equally well safe in both groups. The clinical response to the treatment was seen usually within first 2-3 weeks, those who did not respond early tended not to respond later on as well. Additionally, if not responding to low doses of risperidone (0.5-1 mg/day), patients usually did not respond to higher doses or could not tolerate them, mainly due to emerging extrapyramidal symptoms (EPS). Low doses of risperidone were well tolerated, with the fraction of patients experiencing EPS not achieving 10%. EPS observed, were dose dependent and tended to appear if the dose acceleration was fast. We then recommend low doses of risperidone and its slow titration if needed.

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Items that were most often rated as being improved were related Buy Generic Amoxicillin Online to frontal systems function, including attentional capacity and initiative. Behavioral symptoms that were among the highest rated items were apathy, mood, and agitation. The top two other items were social interactions and involvement in domestic activities. Of the top ten symptomatic treatment effects, only four appeared to be readily identified by current standard measures.

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MD, ONH blood flow, and rCBF were improved significantly after 6 months of the treatment, although IOP did not change significantly. No deterioration of NTG morbidity was found in any of the measured parameters after 12 months of the treatment. Buy Azithromycin In Uk

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22 DLBs and 23 PDDs were assessed over 20 weeks using the Cognitive Drug Research Computerized Attentional Tasks. We examined how much closer our patients moved towards being normal for their age by comparing them to a non-demented elderly control sample (n = 183, aged 71-75 years).

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These pilot data suggest the efficacy and safety of donepezil in the treatment of bipolar disorder. To our knowledge this is the first published report on the use of donepezil in the treatment of mood disorders. Controlled, randomized, double-blind studies are necessary to validate these preliminary observations.