The most common side effects associated with Divalproex are:
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Side effect occurrence does not only depend on medication you are taking, but also on your
overall health and other factors.
Do not take Depakote if you are allergic to Depakote components.
Do not take Depakote if you are pregnant, planning to become pregnant, or are breast-feeding.
Do not take medicines which cause sleepiness.
Be careful if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement.
Be careful with Depakote if you suffer from or have a history of vomiting, extreme tiredness and/or irritability; episodes of confusion and loss of ability to think and understand, especially during pregnancy or after childbirth; coma (loss of consciousness for a period of time); difficulty coordinating your movements; human immunodeficiency virus (HIV); cytomegalovirus (CMV; a virus that can cause symptoms in people who have weak immune systems); hyperlipidemia (higher than normal amount of fats in the blood); or kidney disease, urea cycle disorder, mental retardation.
Be careful with Depakote if you take aspirin, barbiturates such as phenobarbital and seconal blood thinners such as Coumadin, Cyclosporine (Sandimmune, Neoral), Nortriptyline (Pamelor), clonazepam (Klonopin), ethosuximide (Zarontin), felbamate (Felbatol), lamotrigine (Lamictal), phenytoin (Dilantin), and Primidone Mysoline), Rifampin (Rifater, Rimactane), Sleep aids such as Halcion, Tolbutamide (Orinase),Tranquilizers such as Valium and Xanax, Zidovudine (Retrovir), Amitriptyline (Elavil), carbamazepine (Tegretol), Merrem IV (meropenem for injection).
If you experience drowsiness and dizziness while taking Depakote you should avoid any activities such as driving or operating machinery.
Avoid alcohol while taking Depakote.
Avoid being dehydrating.
If you are going to have a surgery, be careful with Depakote.
It can be dangerous to stop Depakote taking suddenly.