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Donepezil (Aricept)

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Generic Aricept is an effective medication which helps to fight with moderate or mild dementia as a result of Alzheimer's disease. It also improves the ability of patients with Alzheimer's disease to think, to reason, to perceive, to judge, to remember, to recognize. Generic Aricept acts by making the nerve cells in the brain work harder and by detaining the neurotransmitter acetycholine breakdown.

Other names for this medication:
Aldomer, Alzaimax, Alzim, Alzit, Ameloss, Aripez, Asenta, Calofra, Carencil, Cebrocal, Cogiton, Crialix, Cristaclar, Dazolin, Doenza, Domepezil, Donaz, Donecept, Donecil, Donectil, Donepex, Donepezilo, Donepezilum, Donesyn, Donethon, Donopez, Dopezil, Dozept, Dozilax, Dozyl, Elzer, Endoclar, Eranz, Evimal, Fordesia, Kibilis, Lirpan, Memac, Memorin, Memorit, Nepezil, Oldinot, Onefin, Redumas, Symepezil, Synpezil, Valpex, Yasnal

Similar Products:
Galantamine, Rivastigmine


Also known as:  Aricept.


Generic Aricept is a perfect remedy, which helps to fight with moderate or mild dementia as a result of Alzheimer's disease. It also improves the ability of patients with Alzheimer's disease to think, to reason, to perceive, to judge, to remember, to recognize.

Generic Aricept acts by making the nerve cells in the brain work harder and by detaining the neurotransmitter acetycholine breakdown. It is cholinesterase inhibitor.

Aricept is also known as Donepezil.

Generic name of Generic Aricept is Donepezil.

Brand names of Generic Aricept are Aricept, Aricept ODT.


The tablet should be dissolved on your tongue and then you should drink water.

Do not crush or chew it.

The usual dose is 5 mg-10 mg a day.

Take Generic Aricept tablets orally with or without food, at the same time every day at bedtime.

Take Generic Aricept once a day.

If you want to achieve most effective results do not stop taking Generic Aricept suddenly.


If you overdose Generic Aricept and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Aricept: slow heartbeat, seizure, vomiting, shallow breathing, weak muscle, drooling, severe nausea, blurred vision, dizziness, sweating.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Donepezil are:

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  • where to buy donepezil
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  • buy donepezil hydrochloride
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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Generic Aricept if you are allergic to Generic Aricept components.

Do not take Generic Aricept if you are pregnant, planning to become pregnant. Do not breast-feed while taking Generic Aricept.

Be careful with Generic Aricept if you take hyoscyamine (such as Levsin, Anaspaz, Cystospaz); glycopyrrolate (such as Robinul); rifampin (such as Rifater, Rifadin, Rifamate); a fungal antibiotic (itraconazole (such as Sporanox), ketoconazole (such as Nizoral), fluconazole (such as Diflucan)); atropine (such as Donnatal); propantheline (such as Pro-Banthine); aspirin or other NSAIDs (mefenamic acid (such as Ponstel), piroxicam (such as Feldene), indomethacin (such as Indocin), ibuprofen (such as Advil, Motrin), naproxen (such as Naprosyn, Aleve), diclofenac (such as Voltaren), etodolac (such as Lodine), flurbiprofen (such as Ansaid), ketoprofen (such as Orudis), ketorolac (such as Toradol), meloxicam (such as Mobic)); mepenzolate (such as Cantil); belladonna; scopolamine (such as Transderm-Scop), methscopolamine (such as Pamine); quinidine (such as Quinaglute, Cardioquin, Quinidex); carbamazepine (such as Tegretol); phenobarbital (such as Solfoton, Luminal); clidinium (such as Quarzan); dicyclomine (such as Bentyl); phenytoin (such as Dilantin); dexamethasone (such as Decadron), methantheline (such as Provocholine); nabumetone (such as Relafen), diflunisal (such as Dolobid).

Be very careful with Generic Aricept if you suffer from or have a history of enlarged prostate, heart rhythm or seizure disorder, epilepsy, problems with urination, asthma, obstructive pulmonary disease.

Be careful with this drug if you are going to have a surgery.

Avoid driving machinery.

It can be dangerous to stop Generic Aricept taking suddenly.

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The strain this condition exerts on the healthcare system is increasing yearly. In spite of the large increase in the medication utilization over the previous years, the proportion of treated patients is still small, and further increase in their use is to be expected. It is necessary to monitor this in the years ahead.

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Lower pretreatment rCBF levels in the right orbitofrontal cortex (OFC) predicted a better improvement in the ADAS-cog score in response to donepezil therapy. The severity of SH did not appear to influence this correlation.

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Incidence of Alzheimer's disease is increasing globally and the current therapy is only symptomatic. Curative treatment is a major lacuna. NAR and RUT are natural flavonoids proven for their pleiotropic pharmacological effects with potential neuroprotective benefits. The study evaluated these flavonoids for their potential to improve the most common form of episodic memory (memory of autobiographical events in relation to time, places etc.) in two differential animal models assessing short-term and long-term memory, respectively. We also found that NAR and RUT were able to reverse both short-term and long-term memory deficits dose dependently in female Wistar rats. Abbreviations used: AD: Alzheimer's disease, AChE: Acetylcholinesterase, COX: Cyclooxygenase, DI: Discriminative index, ITI: Inter trial interval, NAR: Naringin, RUT: Rutin, NORT: Novel object recognition task, NOS: Nitric oxide synthase, QOL: Quality of life, RI: Recognition index, WFI: Water for injection.

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Prevention of neurocognitive decline in patients with brain metastases requires a multimodal approach tailored to each patient's need, avoiding WBRT in some, altering the WBRT plan in others, and/or using neuroprotective prophylaxis in those in whom avoidance cannot be utilized. Likewise treatment will require a personalized combination of strategies optimized to address the patient's symptoms.

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Ethanol extract of fresh LS leaves (LSEE), standardized on the basis of quercetin content, was successively partitioned using various solvents viz., hexane, ethyl acetate, and n-butanol in increasing order of polarity. LSEE (50, 100, and 200 mg/kg) and its various fractions (at a dose equivalent to dose of LSEE exhibiting maximum activity), administered orally for 14 days, were evaluated for their memory enhancing effect against scopolamine-induced (1 mg/kg, i.p.) amnesia in 3-4 months old male Laca mice (n = 6 in each group). The memory enhancing effect was evaluated using behavioural (elevated plus maze, novel object recognition and Morris water maze tests) and biochemical parameters (acetylcholinesterase activity, malonaldehyde, superoxide dismutase, nitrite, catalase, and reduced gultathione content). The results of the test substances were compared with both scopolamine and donepezil that was used as a standard memory enhancer and acetylcholinesterase inhibitor.

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We discuss a case of a 67-year-old male with dementia with Lewy bodies (DLB) that was initially suspected as Creutzfeldt-Jakob disease (CJD) or another type of encephalopathy, because he showed rapidly progressive deterioration, myoclonus, gait disturbance and a decline in activities of daily living. The present study describes a clinically atypical case with probable DLB and reviews similar cases in the literature, and we propose a rapidly progressive clinical subtype of DLB.

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Phencyclidine (PCP) induces a behavioral syndrome in rodents that bears remarkable similarities to some of the core symptoms observed in schizophrenic patients, among those cognitive deficits. The successful alleviation of cognitive impairments associated with schizophrenia (CIAS) has become a major focus of research efforts as they remain largely untreated. The aim of the present study was to investigate the effects of selected antipsychotic and cognition enhancing drugs, namely haloperidol, risperidone, donepezil, and modafinil in an animal model widely used in preclinical schizophrenia research. To this end, the novel object recognition (NOR) task was applied to rats abstinent following sub-chronic treatment with PCP. Rats were administered either PCP (5 mg/kg, i.p.) or vehicle twice a day for 7 days, followed by a 7-day washout period, before testing in NOR. Upon testing, vehicle-treated rats successfully discriminated between novel and familiar objects, an effect abolished in rats that had previously been exposed to PCP treatment. Acute treatment with modafinil (64 mg/kg, p.o.) ameliorated the PCP-induced deficit in novel object exploration, whereas haloperidol (0.1 mg/kg, s.c.), risperidone (0.2 mg/kg, i.p.), and donepezil (3 mg/kg, p.o.) were without significant effect. Given the negligible efficacy of haloperidol and risperidone, and the contradictory data with donepezil to treat CIAS in the clinic, together with the promising preliminary pro-cognitive effects of modafinil in certain subsets of schizophrenic patients, the sub-chronic PCP-NOR abstinence paradigm may represent an attractive option for the identification of potential novel treatments for CIAS.

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The therapeutic approach is planned according to the different phases of the disease. In the preclinical phase, anti-inflammatory drugs and estrogens in post-menopausal women have been effective. In the initial phase current recognition therapy is directed basically towards correcting the break-down of acetylcholine (tacrine, donepezil, SB202026, SDZ ENA 713). For depressive symptoms serotonin levels are corrected using selective inhibitors of serotonin uptake.

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Mice were given an intracerebroventricular (i.c.v.) injection of Abeta(25-35) peptide (9 nmol) 7-9 days before being tested for spontaneous alternation and passive avoidance. Hippocampal lipid peroxidation was measured 7 days after Abeta(25-35) injection to evaluate oxidative stress. Donepezil, the sigma(1) agonist PRE-084 or the cholinesterase (ChE) inhibitors tacrine, rivastigmine and galantamine were administered either 20 min before behavioural sessions to check their anti-amnesic effects, or 20 min before Abeta(25-35) injection, or 24 h after Abeta(25-35) injection and then once daily before behavioural sessions, to check their pre- and post-i.c.v. neuroprotective activity, respectively.

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One-year persistence rates were similar between different ChEIs. Among patients persisting with ChEI medication for at least 12 months, users of donepezil were slightly more likely to continue to persist at 24 months. Nearly half of patients failed to persist with ChEI therapy for at least 12 months. Our findings underscore the limitations of the ChEI medications and the urgent need for effective and tolerable therapeutic options for patients having dementia.

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buy aricept canada 2016-08-24

Donepezil and antidepressant therapy temporarily improved global cognition (treatment × time interaction, F₂,₂₁₆ = 3.78; P = .03), but effect sizes were small (Cohen d = 0.27, group difference at 1 year). A marginal benefit to Buy Cheap Cefixime Online cognitive instrumental activities of daily living was also observed (treatment × time interaction, F₂,₁₃₇ = 2.94; P = .06). The donepezil group was more likely than the placebo group to experience recurrent major depression (35% [95% confidence interval {CI}, 24%-46%] vs 19% [95% CI, 9%-29%], respectively; log-rank χ² = 3.97; P = .05; hazard ratio = 2.09 [95% CI, 1.00-4.41]). Post hoc subgroup analyses showed that of 57 participants with mild cognitive impairment, 3 of 30 participants (10% [95% CI, 0%-21%]) receiving donepezil and 9 of 27 participants (33% [95% CI, 16%-51%]) receiving placebo had a conversion to dementia over 2 years (Fisher exact test, P = .05). The mild cognitive impairment subgroup had recurrence rates of major depression of 44% with donepezil vs 12% with placebo (likelihood ratio = 4.91; P = .03). The subgroup with normal cognition (n = 73) showed no benefit with donepezil and no increase in recurrence of major depression.

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The average age of patients was 63.4 years (range, 49-84 years). The indication for surgery (by record review) included 9 patients with essential tremor, 31 with Parkinson disease, and 1 with dystonia. The diagnoses after referral examination included 5 with essential tremor, 26 with Parkinson disease, 3 with Parkinson disease and dementia, 1 with Parkinson disease and essential tremor, 1 with corticobasal degeneration, 1 with dystonia, 2 with multiple system atrophy, 1 with progressive supranuclear palsy, and 1 with myoclonus. Issues related to inadequate preoperative screening: Thirty (73%) of 41 patients saw a movement disorders specialist prior to DBS implantation. Fourteen (34%) patients had neuropsychological testing, 4 (10%) did not have testing, and in 23 cases (56%), it could not be determined whether or not they were tested. Five (12%) of 41 patients had an inadequate medication trial, and 5 patients (12%) had significant cognitive dysfunction prior to their DBS implantation. Surgical and device-related complications: Nineteen (46%) of 41 patients had suboptimally placed electrodes. Seven electrodes (17%) were replaced with improvement. Three patients' devices had failed due to end of battery life, 2 had infections, and 1 had a fractured lead. Programming and medication adjustments: Seven (17%) of 41 patients had no or poor access to programming. Two patients (5%) moved, and 2 physicians (5%) moved, creating issues with access to care. Eight patients (20%) required Buy Amoxil Online local follow-up (they flew to remote centers to have the surgery performed). Fifteen patients (37%) were inadequately programmed and improved significantly with reprogramming. Six patients (15%) experienced partial improvement with reprogramming, and 21 patients (51%) failed to improve despite extensive reprogramming. Thirty patients (73%) benefited from medication changes, 4 (10%) had antidepressants added to their regimens, and 1 (2%) had donepezil hydrochloride added. One patient's carbidopa/levodopa (2%) was restarted after complete discontinuation.

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The study findings suggest that physicians who specialized in psychiatry and neurology predominantly provided ambulatory care services for dementia patients. More efforts should be given to detect and to treat dementia Buy Cleocin Online patients with cognitive-enhancing agents after the formal diagnosis in the ambulatory care setting.

buy donepezil canada 2015-06-14

Alternatives to psychostimulants are now a routine part of the pharmacologic treatment of ADHD. Bupropion and most tricyclic antidepressants are sound options for managing core behavioral symptoms and, to some extent, cognitive symptoms. Alpha 2 adrenergic agonists can moderately reduce hyperactivity and impulsivity. Certain effective agents, Buy Cymbalta Generic such as desipramine, carbamazepine, neuroleptics, monoamine oxidase inhibitors, are clinically inadvisable in most cases. Lithium, benzodiazepines, antihistaminic sedatives, and buspirone are potentially detrimental. Venlafaxine and beta-adrenergic blockers seem potentially promising. Significant new options include norepinephrine reuptake inhibitors, such as reboxetine and tomoxetine, and possibly selective dopamine agonists. Central anticholinesterases, such as donepezil, may improve core ADHD symptoms and perhaps some associated features that psychostimulants do not--particularly organizational capacity and possibly other executive functions. The potential for bupropion to treat amotivational features should be investigated.

buy donepezil 2016-10-20

The clinical effectiveness systematic review was undertaken following the principles published by the NHS CRD. We included RCTs whose population was people with AD. The intervention and comparators depended on disease severity, measured by the Buy Vigrx Plus Uae Mini Mental State Examination (MMSE).

buy donepezil hydrochloride 2016-06-16

This was a 26-week open-label extension (OLE) of a prospective, 26-week, open-label, single-arm, multicenter study conducted in the United States from October 2003 to January 2005. Patients had a diagnosis of Alzheimer's disease according to DSM-IV-TR and National Institute of Neurologic and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association criteria. Safety and tolerability of rivastigmine were monitored through Buy Diamox Online India monthly telephone contacts. At week 52, patients or caregivers were contacted by telephone to evaluate the patient's well-being.

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Both IHC and Western blot revealed a decrease in SYP levels in the CA1 region of 7- and 11-month-old APPV717I Buy Spironolactone Online Uk transgenic mice compared with the control groups, whereas SYP levels were increased in donepezil- and GEPT-treated transgenic mice compared with the APP group. There was a significant difference in the levels of SYP detected by IHC between the GEPT high-dose group and the APP group after 4 months of treatment, and there were significant differences between all three GEPT groups and the APP group after 8 months of treatment. Western blotting showed that the SYP protein-β-actin ratio was decreased in APP mice, while donepezil- and GEPT-treated transgenic mice showed increased trends in the SYP protein-β-actin ratios.

buy donepezil uk 2016-07-18

Compared with the model group, the 3rd - 5th day escape latency were all shortened in each medication group. The expressions of Bax, Abeta, and betaAPP decreased in the cortex and hippocampus. The numbers of platform crossing increased. The expression of Bcl-2 in the cortex increased. The expression of Bcl-2 in the hippocampus increased in the donepezil hydrochloride group and the QLR group with statistical difference (P<0.01, P<0.05). Compared with the donepezil hydrochloride group, the expression of betaAPP increased in the cortex and hippocampus of the saponin group. The expression of Abeta in the cortex and hippocampus decreased, the expression of Bax in the hippocampus decreased, and the expression of Bcl-2 in the cortex increased in the QLR group. The escape latency was obviously Buy Vigrx Plus Amazon postponed at day 3 -5, the platform crossing times decreased, the expression of Bcl-2 in the cortex and hippocampus decreased in the saponin group, showing statistical difference (P<0.05, P<0.01).

buy aricept cheap 2015-01-20

To evaluate the efficacy Zithromax 500 Mg Cheap and safety of donepezil, an acetylcholinesterase inhibitor, as a treatment for cognitive impairment and dementia in patients with Parkinson' s disease (PD).