To study the efficacy of Ashwagandha and Guduchi in oxidative stress in healthy volunteers.
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Guduchi Ghana is one of the unique Ayuvedic classical preparation which is prepared from aqueous of extract of Guduchi (Tinospora cordifolia Miers.) stem. It is one of the frequently used drugs to treat the Madhumeha, Pandu, Kamala, Amlapitta, Grahani, Kustha, Jirna Jwara and Viswamjwara, Trishna, Shool, Yakritavikara, etc. Looking to these indications, in market most of the Pharma industries prepared Guduchi Ghana by applying the various extraction process.
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Tinospora cordifolia (Guduchi) has been used for centuries for treating various ailments including cancer in Ayurvedic system of medicine. In this study, we report the mechanism of cell death exhibited by the hexane extract fraction of T. cordifolia (TcHf) against Ehrlich ascites tumor (EAT) in mice. Treatment of EAT bearing animals with TcHf resulted in growth inhibition and induction of apoptosis in a dose-dependent manner. TcHf induced the formation of apoptotic bodies, nuclear condensation, typical DNA ladder, activation of caspase-3, decreased cell number and ascites volume. We examined TcHf for its effect on proliferation and cell cycle progression in EAT cells. The results showed that TcHf inhibited the proliferation of EAT cells by blocking cell cycle progression in the G1 phase. In Western blot analysis, apoptosis in the EAT cells was associated with the constitutive expression of caspase activated DNase (CAD) in both nucleus and cytoplasm after TcHf treatment. Further more the expression of pro-apoptotic gene, Bax, was increased and the expression of anti-apoptotic gene, Bcl-2, was decreased in a time dependent manner by TcHf treatment. All results indicate that the hexane fraction of T. cordifolia is capable of inducing apoptosis in EAT cells in vivo.
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Tinospora cordifolia also known as Giloy or Guduchi, is an indigenous climber plant indigenous to tropical areas of India, Myanmar and Sri Lanka. Its stem is used for treatment of fever, jaundice, emaciation, skin ailments, diabetes, anaemia and various infectious diseases. The study was undertaken to evaluate the proximate and elemental analysis of the stems of Tinospora cordifolia. The proximate analyses were carried out using standard methods, while mineral elements were analyzed using Atomic Absorption Spectrophotometer, equipped with air acetylene flame. The proximate analysis of the stems of Tinospora cordifolia showed that it contained moisture 34.39%, ether extract 0.912%, crude protein 7.74%, crude fibre 56.42%, total ash 7.96%, nitrogen free extract 26.97%, cellulose 23.02% and hemicellulose 3.70%. The mineral analysis of the stems showed that they contain the following essential minerals: Calcium (102.23 ppm), phosphorous (24.81 ppm), iron (26.058 ppm), copper (3.733 ppm), zinc (7.342 ppm) and manganese (12.242 ppm). The study revealed that Tinospora cordifolia stems to be a potential source of nutrition and minerals for man as well as animals.
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The confirmation of an immunomodulatory protein in guduchi stem showing lymphoproliferative and macrophage-activating properties reinforces the rationale of the use of guduchi preparations in several Ayurvedic medicines for immunomodulation. To our knowledge, this is the first report of an immunomodulatory protein isolated from guduchi.