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Myambutol (Ethambutol)

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Myambutol (generic name: ethambutol; brand names include: EMB / Etibi / Combutol / Mycobutol / Tibitol / Servambutol / Tibinil) belongs to a group of medicines called antitubercular agents. Myambutol is used for the treatment of pulmonary tuberculosis, usually in combination with other antituberculosis medicines.

Other names for this medication:
Althocin, Amiobutols, Apo-ethambutol, Bacbutol, Combutol, Corsabutol, Dexambutol, Ebutol, Ecox, Emb-fatol, Esanbutol, Etambutol, Etapiam, Etham, Ethambutolo, Ethambutolum, Etibi, Fiambutol, Macox, Miambutol, Mycobutol, Niazitol, Oributol, Pharex ethambutol, Phthizoetham, Pulna, Rifafour, Rimstar, Santibi, Servambutol, Sural, Themibutol, Tibitol, Tibutol, Turresis

Similar Products:
Moxifloxacin, Streptomycin, Etibi, Rifadin, Rofact, Levaquin, Avelox, Mycobutin


Also known as:  Ethambutol.


Myambutol is a prescription medication used to treat tuberculosis (TB). Myambutol belongs to a group of drugs called antimycobacterial antibiotics. TB is caused by a certain bacteria. Myambutol works by stopping the bacteria from forming a cell wall, which kills the bacteria.

This medication comes in tablet form. It is taken once a day with or without food.

Common side effects of Myambutol include loss of appetite, upset stomach, and numbness or tingling in hands and feet.


Initial Treatment: In patients who have not received previous antituberculous therapy, administer Myambutol 15 mg/kg (7 mg/ lb) of body weight, as a single oral dose once every 24 hours. In the more recent studies, isoniazid has been administered concurrently in a single, daily, oral dose.

Retreatment: In patients who have received previous antituberculous therapy, administer Myambutol 25 mg/kg (11 mg/lb) of body weight, as a single oral dose once every 24 hours. Concurrently administer at least one other antituberculous drug to which the organisms have been demonstrated to be susceptible by appropriate in-vitro tests. Suitable drugs usually consist of those not previously used in the treatment of the patient. After 60 days of Myambutol administration, decrease the dose to 15 mg/kg (7mg/ lb) of body weight, and administer as a single oral dose once every 24 hours.

During the period when a patient is on a daily dose of 25 mg/kg, monthly eye examinations are advised.


If you take too much Myambutol, call your local Poison Control Center or seek emergency medical attention right away.


Store at room temperature (20 to 25 degrees C [68 to 77 degrees F]) away from light and moisture. Keep this and all medicines out of the reach of children.

Side effects

The most common side effects associated with Myambutol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Lab tests, including liver and kidney function, complete blood cell counts, and vision, may be performed while you use Myambutol. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Myambutol should not be used in CHILDREN younger than 13 years old; safety and effectiveness in these children have not been confirmed.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Myambutol while you are pregnant. Myambutol is found in breast milk. If you are or will be breast-feeding while you use Myambutol, check with your doctor. Discuss any possible risks to your baby.

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Information on the biosynthesis of the D-arabinans of the cell wall of Mycobacterium tuberculosis is rapidly emerging, with the promise of new targets for drug development against tuberculosis. Accordingly, arabinosyl transferase assays were developed utilizing synthesized [1-14C]-beta-D-arabinofuranosyl-1-monophosphoryldecaprenol as donor and a variety of O- and S-alkyl arabinosides as acceptors. These were: alpha-D-Araf-(1-->5)-alpha-D-Araf-O- and -S-alkyl diarabinosides and alpha-D-Araf-(1-->5)-alpha-D-Araf-(1-->5)-alpha-D-Araf -O- and -S-alkyl triarabinosides. Whereas the O- and S-alkyl monosaccharide acceptors were inactive, the O- and S-alkyl disaccharide and the O- and S-alkyl trisaccharide acceptors (5) arabinosyl transferase and beta-D-arabinofuranosyl-1-monophosphoryldecaprenol: arabinan beta(1-->2) arabinosyl transferase. The beta(1-->2) arabinosyl transferase activity was more in evidence in the presence of the O-alkyl disaccharide acceptor, whereas both transferases were about equivalent in the presence of the S-alkyl trisaccharide acceptor. The tuberculosis drug, ethambutol, a known mycobacterial arabinosyl transferase inhibitor, was inactive within these arabinosyl transferase/acceptor based assay systems, supporting other evidence that a third activity, responsible for the formation of alpha1-->3 linkage, is the drug target.

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A retrospective review of medical records of TB cases meeting Buy Orlistat Capsules 120mg the study criteria, a Mycobacterium tuberculosis isolate resistant to isoniazid, and intent to treat with a 6-month course of isoniazid, rifampin, pyrazinamide, and ethambutol.